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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7dfbdafcfc1640e899512df47529113f

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

About this item

Full title

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Publisher

London: Nature Publishing Group UK

Journal title

EMBO molecular medicine, 2018-11, Vol.10 (11), p.1-n/a

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associated TREM2 variants to various forms of Aβ and APOE in multiple assays. TREM2 interacts directly with various fo...

Alternative Titles

Full title

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7dfbdafcfc1640e899512df47529113f

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7dfbdafcfc1640e899512df47529113f

Other Identifiers

ISSN

1757-4676

E-ISSN

1757-4684

DOI

10.15252/emmm.201809027

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