Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease in...
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease inhibitors are found in the protease's active site that serves also as a binding pocket for the protease inhibitors,...
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Full title
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_7e14234516e447aa8834a2af7952a526
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7e14234516e447aa8834a2af7952a526
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ISSN
1742-4690
E-ISSN
1742-4690
DOI
10.1186/s12977-020-00520-6
