Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzhei...
Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
Familial Alzheimer's disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Aβ) production-independent manner. This gain-of-function enhancement of IP3R activity is considered to be the main reason behind the...
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Full title
Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins
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TN_cdi_doaj_primary_oai_doaj_org_article_7e5e2b104e7e4abd990ca3f49c1e90de
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7e5e2b104e7e4abd990ca3f49c1e90de
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1004529
