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Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7e8f2306aea34783a1ca07f753e296b9

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (
HTT
). Here we have studied constitutional
HTT
CAG repeat size in two cohorts of individuals with Lynch syndrome (LS) carrying heterozy...

Alternative Titles

Full title

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7e8f2306aea34783a1ca07f753e296b9

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7e8f2306aea34783a1ca07f753e296b9

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-024-54277-5

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