SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory acti...
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
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Author / Creator
Olagnier, David , Farahani, Ensieh , Thyrsted, Jacob , Blay-Cadanet, Julia , Herengt, Angela , Idorn, Manja , Hait, Alon , Hernaez, Bruno , Knudsen, Alice , Iversen, Marie Beck , Schilling, Mirjam , Jørgensen, Sofie E. , Thomsen, Michelle , Reinert, Line S. , Lappe, Michael , Hoang, Huy-Dung , Gilchrist, Victoria H. , Hansen, Anne Louise , Ottosen, Rasmus , Nielsen, Camilla G. , Møller, Charlotte , van der Horst, Demi , Peri, Suraj , Balachandran, Siddharth , Huang, Jinrong , Jakobsen, Martin , Svenningsen, Esben B. , Poulsen, Thomas B. , Bartsch, Lydia , Thielke, Anne L. , Luo, Yonglun , Alain, Tommy , Rehwinkel, Jan , Alcamí, Antonio , Hiscott, John , Mogensen, Trine H. , Paludan, Søren R. and Holm, Christian K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-O...
Alternative Titles
Full title
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Authors, Artists and Contributors
Author / Creator
Farahani, Ensieh
Thyrsted, Jacob
Blay-Cadanet, Julia
Herengt, Angela
Idorn, Manja
Hait, Alon
Hernaez, Bruno
Knudsen, Alice
Iversen, Marie Beck
Schilling, Mirjam
Jørgensen, Sofie E.
Thomsen, Michelle
Reinert, Line S.
Lappe, Michael
Hoang, Huy-Dung
Gilchrist, Victoria H.
Hansen, Anne Louise
Ottosen, Rasmus
Nielsen, Camilla G.
Møller, Charlotte
van der Horst, Demi
Peri, Suraj
Balachandran, Siddharth
Huang, Jinrong
Jakobsen, Martin
Svenningsen, Esben B.
Poulsen, Thomas B.
Bartsch, Lydia
Thielke, Anne L.
Luo, Yonglun
Alain, Tommy
Rehwinkel, Jan
Alcamí, Antonio
Hiscott, John
Mogensen, Trine H.
Paludan, Søren R.
Holm, Christian K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7eb1ed3741cc4fbfa366937b0037cc35
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7eb1ed3741cc4fbfa366937b0037cc35
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18764-3
