Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial enc...
Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two different CNS-deficient mouse models (
Ndufs3
/complex I or
Cox10
/complex IV conditional knockouts) to gene therap...
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Full title
Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy
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TN_cdi_doaj_primary_oai_doaj_org_article_7ee838787fdb4b8a8f0b8075974cedd6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7ee838787fdb4b8a8f0b8075974cedd6
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ISSN
1757-4684
E-ISSN
1757-4684
DOI
10.1038/s44321-024-00111-4
