Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
About this item
Full title
Author / Creator
Bonacina, Fabrizia , Coe, David , Wang, Guosu , Longhi, Maria P. , Baragetti, Andrea , Moregola, Annalisa , Garlaschelli, Katia , Uboldi, Patrizia , Pellegatta, Fabio , Grigore, Liliana , Da Dalt, Lorenzo , Annoni, Andrea , Gregori, Silvia , Xiao, Qingzhong , Caruso, Donatella , Mitro, Nico , Catapano, Alberico L. , Marelli-Berg, Federica M. and Norata, Giuseppe D.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells (DC), resulting in enhanced MHC-II-dependent antigen presentation and CD4
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T-cell activation. Results from WT and apoE KO bone marrow...
Alternative Titles
Full title
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Authors, Artists and Contributors
Author / Creator
Coe, David
Wang, Guosu
Longhi, Maria P.
Baragetti, Andrea
Moregola, Annalisa
Garlaschelli, Katia
Uboldi, Patrizia
Pellegatta, Fabio
Grigore, Liliana
Da Dalt, Lorenzo
Annoni, Andrea
Gregori, Silvia
Xiao, Qingzhong
Caruso, Donatella
Mitro, Nico
Catapano, Alberico L.
Marelli-Berg, Federica M.
Norata, Giuseppe D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7efaea98bd784e4796780b5a4dbced26
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7efaea98bd784e4796780b5a4dbced26
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05322-1
