Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon...
Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
SARM1 is a central executioner of programmed axon death, and this role requires intrinsic NAD(P)ase or related enzyme activity. A complete absence of SARM1 robustly blocks axon degeneration in mice, but even a partial depletion confers meaningful protection. Since axon loss contributes substantially to the onset and progression of multiple neurodeg...
Alternative Titles
Full title
Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7f17fb24f1fc49849a24f8c3c7c31436
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f17fb24f1fc49849a24f8c3c7c31436
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-18052-8
