The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection
The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In
Streptococcus pyogenes
, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Although FabT defects confer reduced virulence in animal models, spontaneous
fabT
mutants arise in vivo. We resolved this paradox by characterizing the conditions and mechani...
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Full title
The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection
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TN_cdi_doaj_primary_oai_doaj_org_article_7f491b6bc68941ea8141f6da9848c69d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f491b6bc68941ea8141f6da9848c69d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-52637-3
