Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure an...
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
About this item
Full title
Author / Creator
Vuckovic, Ziva , Wang, Jinan , Pham, Vi , Mobbs, Jesse I , Belousoff, Matthew J , Bhattarai, Apurba , Burger, Wessel AC , Thompson, Geoff , Yeasmin, Mahmuda , Nawaratne, Vindhya , Leach, Katie , van der Westhuizen, Emma T , Khajehali, Elham , Liang, Yi-Lynn , Glukhova, Alisa , Wootten, Denise , Lindsley, Craig W , Tobin, Andrew , Sexton, Patrick , Danev, Radostin , Valant, Celine , Miao, Yinglong , Christopoulos, Arthur and Thal, David M
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR allosteric modulators remains limited. The M
4
muscarinic acetylcholine receptor (M
4
mA...
Alternative Titles
Full title
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Authors, Artists and Contributors
Author / Creator
Wang, Jinan
Pham, Vi
Mobbs, Jesse I
Belousoff, Matthew J
Bhattarai, Apurba
Burger, Wessel AC
Thompson, Geoff
Yeasmin, Mahmuda
Nawaratne, Vindhya
Leach, Katie
van der Westhuizen, Emma T
Khajehali, Elham
Liang, Yi-Lynn
Glukhova, Alisa
Wootten, Denise
Lindsley, Craig W
Tobin, Andrew
Sexton, Patrick
Danev, Radostin
Valant, Celine
Miao, Yinglong
Christopoulos, Arthur
Thal, David M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7f71dbdee2334fc988c8a96b377f0938
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f71dbdee2334fc988c8a96b377f0938
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.83477
