Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal...
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations
About this item
Full title
Author / Creator
Marsan, Elise , Velmeshev, Dmitry , Ramsey, Arren , Patel, Ravi K. , Zhang, Jiasheng , Koontz, Mark , Andrews, Madeline G. , de Majo, Martina , Mora, Cristina , Blumenfeld, Jessica , Li, Alissa N. , Spina, Salvatore , Grinberg, Lea T. , Seeley, William W. , Miller, Bruce L. , Ullian, Erik M. , Krummel, Matthew F. , Kriegstein, Arnold R. and Huang, Eric J.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical circuit in Grn-/- mice, the exact mechanism for neurodegeneration in FTLD-GRN remains unclear. By perfo...
Alternative Titles
Full title
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations
Authors, Artists and Contributors
Author / Creator
Velmeshev, Dmitry
Ramsey, Arren
Patel, Ravi K.
Zhang, Jiasheng
Koontz, Mark
Andrews, Madeline G.
de Majo, Martina
Mora, Cristina
Blumenfeld, Jessica
Li, Alissa N.
Spina, Salvatore
Grinberg, Lea T.
Seeley, William W.
Miller, Bruce L.
Ullian, Erik M.
Krummel, Matthew F.
Kriegstein, Arnold R.
Huang, Eric J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7f87fa9f28bd4ee9be391db5a7643359
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f87fa9f28bd4ee9be391db5a7643359
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI164919
