Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding
Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). We used a novel approach involving labeling of intact channels in a native, membrane environment with a non-canonical fluorescent amino acid and measurement (using FRET with fluorescent nucleotides) of steady-sta...
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Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding
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TN_cdi_doaj_primary_oai_doaj_org_article_7f916e61f8a14fc0a7f9a33162e35c07
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f916e61f8a14fc0a7f9a33162e35c07
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.41103