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Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f916e61f8a14fc0a7f9a33162e35c07

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

About this item

Full title

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2019-02, Vol.8

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). We used a novel approach involving labeling of intact channels in a native, membrane environment with a non-canonical fluorescent amino acid and measurement (using FRET with fluorescent nucleotides) of steady-sta...

Alternative Titles

Full title

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7f916e61f8a14fc0a7f9a33162e35c07

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f916e61f8a14fc0a7f9a33162e35c07

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.41103

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