Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resist...
Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphonoethylamine
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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The mechanisms of NASH development in the context of age and genetics are not fully elucidated. This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (
Pcyt2
+
/−
)
,
the rate limiting enzyme in phosphatidylethanolamine (PE) synthesis. Further, the therapeutic p...
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Full title
Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphonoethylamine
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TN_cdi_doaj_primary_oai_doaj_org_article_7fbdcffd68bb48f68c63e46d0d6a0593
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7fbdcffd68bb48f68c63e46d0d6a0593
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-05140-y
