E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer
E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the signal peptide of E-cadherin without changing the remaining predicted sequence. We verified that p.L13_L15del cells yield low levels of E-c...
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Full title
E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_7ff09f3f7a124c11ba668e246b5162a2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7ff09f3f7a124c11ba668e246b5162a2
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-018-0859-0
