Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory ner...
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
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England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse model of PD, elicited retrograde trans-synaptic spreading of α-Syn pathology (pSer129) across sensory neurons and...
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Full title
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
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TN_cdi_doaj_primary_oai_doaj_org_article_80104fc9b45e4497b166570f57568963
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80104fc9b45e4497b166570f57568963
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01131-8
