A strategy for Cas13 miniaturization based on the structure and AlphaFold
A strategy for Cas13 miniaturization based on the structure and AlphaFold
About this item
Full title
Author / Creator
Zhao, Feiyu , Zhang, Tao , Sun, Xiaodi , Zhang, Xiyun , Chen, Letong , Wang, Hejun , Li, Jinze , Fan, Peng , Lai, Liangxue , Sui, Tingting and Li, Zhanjun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The small size of the Cas nuclease fused with various effector domains enables a broad range of function. Although there are several ways of reducing the size of the Cas nuclease complex, no efficient or generalizable method has been demonstrated to achieve protein miniaturization. In this study, we establish an Interaction, Dynamics and Conservati...
Alternative Titles
Full title
A strategy for Cas13 miniaturization based on the structure and AlphaFold
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_805df6dda3454999869b65dae19f19a3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_805df6dda3454999869b65dae19f19a3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41320-8
