SMC5/6 is required for replication fork stability and faithful chromosome segregation during neuroge...
SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein
Smc5
is conditionally knocked out (cKO) in the developing neocortex.
Smc5
cKO mice exhibited neurodevelopmental defects due to neural progenitor cell (NPC) apoptosis, which led to...
Alternative Titles
Full title
SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_80616597eed84aafa9e4ee3b267f4985
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80616597eed84aafa9e4ee3b267f4985
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.61171
