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Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the t...

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the t...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8066ce4c48e948cba3c554cfbda463aa

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

About this item

Full title

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

Publisher

New Zealand: Taylor & Francis Ltd

Journal title

International journal of nanomedicine, 2018-01, Vol.13, p.2051-2064

Language

English

Formats

Publication information

Publisher

New Zealand: Taylor & Francis Ltd

More information

Scope and Contents

Contents

Triptolide (TP) exhibits immunosuppressive, cartilage-protective and anti-inflammatory effects in rheumatoid arthritis. However, the toxicity of TP limits its widespread use. To decrease the toxic effects, we developed a novel nano-drug carrier system containing TP using poly-γ-glutamic acid-grafted di-tert-butyl L-aspartate hydrochloride (PAT). PA...

Alternative Titles

Full title

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8066ce4c48e948cba3c554cfbda463aa

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8066ce4c48e948cba3c554cfbda463aa

Other Identifiers

ISSN

1178-2013,1176-9114

E-ISSN

1178-2013

DOI

10.2147/IJN.S151233

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