Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mu...
Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia
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Full title
Author / Creator
Bassal, Mahmoud A. , Samaraweera, Saumya E. , Lim, Kelly , Benard, Brooks A. , Bailey, Sheree , Kaur, Satinder , Leo, Paul , Toubia, John , Thompson-Peach, Chloe , Nguyen, Tran , Maung, Kyaw Ze Ya , Casolari, Debora A. , Iarossi, Diana G. , Pagani, Ilaria S. , Powell, Jason , Pitson, Stuart , Natera, Siria , Roessner, Ute , Lewis, Ian D. , Brown, Anna L. , Tenen, Daniel G. , Robinson, Nirmal , Ross, David M. , Majeti, Ravindra , Gonda, Thomas J. , Thomas, Daniel and D’Andrea, Richard J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The interaction of germline variation and somatic cancer driver mutations is under-investigated. Here we describe the genomic mitochondrial landscape in adult acute myeloid leukaemia (AML) and show that rare variants affecting the nuclear- and mitochondrially-encoded complex I genes show near-mutual exclusivity with somatic driver mutations affecti...
Alternative Titles
Full title
Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia
Authors, Artists and Contributors
Author / Creator
Samaraweera, Saumya E.
Lim, Kelly
Benard, Brooks A.
Bailey, Sheree
Kaur, Satinder
Leo, Paul
Toubia, John
Thompson-Peach, Chloe
Nguyen, Tran
Maung, Kyaw Ze Ya
Casolari, Debora A.
Iarossi, Diana G.
Pagani, Ilaria S.
Powell, Jason
Pitson, Stuart
Natera, Siria
Roessner, Ute
Lewis, Ian D.
Brown, Anna L.
Tenen, Daniel G.
Robinson, Nirmal
Ross, David M.
Majeti, Ravindra
Gonda, Thomas J.
Thomas, Daniel
D’Andrea, Richard J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_80997f20894a4c6ab09d4081863d91de
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80997f20894a4c6ab09d4081863d91de
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30223-9
