Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and the loss of iron-sulfur cluster proteins, ultimately resulting in pr...
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Full title
Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
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TN_cdi_doaj_primary_oai_doaj_org_article_809aa2bea689405d8725df5a8b15aaf8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_809aa2bea689405d8725df5a8b15aaf8
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ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-024-01589-8
