Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
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Author / Creator
Schmidt, Nathalie M. , Wing, Peter A. C. , Diniz, Mariana O. , Pallett, Laura J. , Swadling, Leo , Harris, James M. , Burton, Alice R. , Jeffery-Smith, Anna , Zakeri, Nekisa , Amin, Oliver E. , Kucykowicz, Stephanie , Heemskerk, Mirjam H. , Davidson, Brian , Meyer, Tim , Grove, Joe , Stauss, Hans J. , Pineda-Torra, Ines , Jolly, Clare , Jury, Elizabeth C. , McKeating, Jane A. and Maini, Mala K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carcinogenic activity. Here, we show that ACAT inhibition has antiviral activity against hepatitis B (HBV), as well as boosting...
Alternative Titles
Full title
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Authors, Artists and Contributors
Author / Creator
Wing, Peter A. C.
Diniz, Mariana O.
Pallett, Laura J.
Swadling, Leo
Harris, James M.
Burton, Alice R.
Jeffery-Smith, Anna
Zakeri, Nekisa
Amin, Oliver E.
Kucykowicz, Stephanie
Heemskerk, Mirjam H.
Davidson, Brian
Meyer, Tim
Grove, Joe
Stauss, Hans J.
Pineda-Torra, Ines
Jolly, Clare
Jury, Elizabeth C.
McKeating, Jane A.
Maini, Mala K.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_80c091a62a0e452aadda8e67b452162c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80c091a62a0e452aadda8e67b452162c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22967-7
