Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we report that carcinoma-associated fibroblasts (CAFs) induce β5 integrin expression in tumor cells in a TGF-β dependent manner, making them an efficient drug delivery target for...
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Full title
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_80f9f85745054067b544050e7b18b670
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80f9f85745054067b544050e7b18b670
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21858-1
