Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
About this item
Full title
Author / Creator
Kano, Yoshihito , Gebregiworgis, Teklab , Marshall, Christopher B. , Radulovich, Nikolina , Poon, Betty P. K. , St-Germain, Jonathan , Cook, Jonathan D. , Valencia-Sama, Ivette , Grant, Benjamin M. M. , Herrera, Silvia Gabriela , Miao, Jinmin , Raught, Brian , Irwin, Meredith S. , Lee, Jeffrey E. , Yeh, Jen Jen , Zhang, Zhong-Yin , Tsao, Ming-Sound , Ikura, Mitsuhiko and Ohh, Michael
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Deregulation of the RAS GTPase cycle due to mutations in the three
RAS
genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an essential factor in RAS-driven oncogenesis. Despite the emergence of SHP2 inhibitors for the treatment of cancers harbouring mutant KRAS...
Alternative Titles
Full title
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Authors, Artists and Contributors
Author / Creator
Gebregiworgis, Teklab
Marshall, Christopher B.
Radulovich, Nikolina
Poon, Betty P. K.
St-Germain, Jonathan
Cook, Jonathan D.
Valencia-Sama, Ivette
Grant, Benjamin M. M.
Herrera, Silvia Gabriela
Miao, Jinmin
Raught, Brian
Irwin, Meredith S.
Lee, Jeffrey E.
Yeh, Jen Jen
Zhang, Zhong-Yin
Tsao, Ming-Sound
Ikura, Mitsuhiko
Ohh, Michael
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_811fdf81e7164853822f6750cc8b6260
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_811fdf81e7164853822f6750cc8b6260
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-08115-8
