Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodel...
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only
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Grimbert, Lucile , Sanz, Maria-Nieves , Gressette, Mélanie , Rucker-Martin, Catherine , Novotova, Marta , Solgadi, Audrey , Karoui, Ahmed , Gomez, Susana , Bedouet, Kaveen , Jacquet, Eric , Lemaire, Christophe , Veksler, Vladimir , Mericskay, Mathias , Ventura-Clapier, Renée , Piquereau, Jérôme and Garnier, Anne
Publisher
England: BioMed Central
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English
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Publisher
England: BioMed Central
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The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects.
To decipher AMPK roles in the heart, we generated a cardio-specific inducible model of gene deletion of the main cardia...
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Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only
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TN_cdi_doaj_primary_oai_doaj_org_article_81438108d8ef4b59a82a8ad86e49fea4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_81438108d8ef4b59a82a8ad86e49fea4
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ISSN
2042-6410
E-ISSN
2042-6410
DOI
10.1186/s13293-021-00394-z
