Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute...
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
About this item
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Author / Creator
Tron, Adriana E. , Belmonte, Matthew A. , Adam, Ammar , Aquila, Brian M. , Boise, Lawrence H. , Chiarparin, Elisabetta , Cidado, Justin , Embrey, Kevin J. , Gangl, Eric , Gibbons, Francis D. , Gregory, Gareth P. , Hargreaves, David , Hendricks, J. Adam , Johannes, Jeffrey W. , Johnstone, Ricky W. , Kazmirski, Steven L. , Kettle, Jason G. , Lamb, Michelle L. , Matulis, Shannon M. , Nooka, Ajay K. , Packer, Martin J. , Peng, Bo , Rawlins, Philip B. , Robbins, Daniel W. , Schuller, Alwin G. , Su, Nancy , Yang, Wenzhan , Ye, Qing , Zheng, Xiaolan , Secrist, J. Paul , Clark, Edwin A. , Wilson, David M. , Fawell, Stephen E. and Hird, Alexander W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and resistance to anticancer therapies highlighting the potential of Mcl-1 inhibitors as anticancer drugs. Here, we describe AZD5991, a rationally designed macrocyclic mole...
Alternative Titles
Full title
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Belmonte, Matthew A.
Adam, Ammar
Aquila, Brian M.
Boise, Lawrence H.
Chiarparin, Elisabetta
Cidado, Justin
Embrey, Kevin J.
Gangl, Eric
Gibbons, Francis D.
Gregory, Gareth P.
Hargreaves, David
Hendricks, J. Adam
Johannes, Jeffrey W.
Johnstone, Ricky W.
Kazmirski, Steven L.
Kettle, Jason G.
Lamb, Michelle L.
Matulis, Shannon M.
Nooka, Ajay K.
Packer, Martin J.
Peng, Bo
Rawlins, Philip B.
Robbins, Daniel W.
Schuller, Alwin G.
Su, Nancy
Yang, Wenzhan
Ye, Qing
Zheng, Xiaolan
Secrist, J. Paul
Clark, Edwin A.
Wilson, David M.
Fawell, Stephen E.
Hird, Alexander W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_814ff3ef6b204d84917e2b025f3e1da9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_814ff3ef6b204d84917e2b025f3e1da9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07551-w
