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Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the p...

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the p...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8169a08a0cf84a9b98f50732f4d0ad0e

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

About this item

Full title

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2023-01, Vol.13 (1), p.597-12, Article 597

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) integrity and vascular homeostasis. Here, we show that oxidative stress triggered by H
2
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2
exposu...

Alternative Titles

Full title

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8169a08a0cf84a9b98f50732f4d0ad0e

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8169a08a0cf84a9b98f50732f4d0ad0e

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-022-27308-2

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