RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such as mTOR. However, the mechanism by which this occurs is poorly understood. Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1–RUVBL2–RPAP3–PIH1D1) which...
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RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
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TN_cdi_doaj_primary_oai_doaj_org_article_817fe8022b364f6ab87e9c148af5e6d8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_817fe8022b364f6ab87e9c148af5e6d8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03942-1
