Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphoryla...
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, an...
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Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_81b79808dd01406c825d1806af1a047c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_81b79808dd01406c825d1806af1a047c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04735-2
