Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate a...
Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging synthesis makes them difficult to access. This research presents an efficient synthetic approach for PMOs using the
H
-phosphonate approach. The use of phosphonium-type condensing reagents significantly reduced coupl...
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Full title
Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
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TN_cdi_doaj_primary_oai_doaj_org_article_81ea6cf1ee5040e495a01ef4552d0d10
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_81ea6cf1ee5040e495a01ef4552d0d10
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-38698-2
