DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma t...
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor recurrence and poor prognosis of hepatocellular carcinomas (HCC). DNA methyltransferase (DNMT) family is closely linked with OCT4 expression and drug resistance. However, the und...
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DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_81ffe598b12d460aa2b79bcea12cd258
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_81ffe598b12d460aa2b79bcea12cd258
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-019-1442-2
