Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
About this item
Full title
Author / Creator
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. This loop is important for anchoring elongation factor (EF-G for prokaryote or eEF2 for eukaryote) in mRNA translocation. Translation is inhibited after the attack. RIPs therefore may have been...
Alternative Titles
Full title
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8227c97ccac14841a984ff9dc7c6df68
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8227c97ccac14841a984ff9dc7c6df68
Other Identifiers
ISSN
2072-6651
E-ISSN
2072-6651
DOI
10.3390/toxins12030167
