FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregu...
FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
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Author / Creator
Li, Rong , Yan, Xijing , Xiao, Cuicui , Wang, Tingting , Li, Xuejiao , Hu, Zhongying , Liang, Jinliang , Zhang, Jiebin , Cai, Jianye , Sui, Xin , Liu, Qiuli , Wu, Manli , Xiao, Jiaqi , Chen, Haitian , Liu, Yasong , Jiang, Chenhao , Lv, Guo , Chen, Guihua , Zhang, Yingcai , Yao, Jia , Zheng, Jun and Yang, Yang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older livers exhibit increased ferroptosis during HIRI. Inhibiting ferroptosis significantly attenuates older HIRI phenotypes. Mass spectrometry r...
Alternative Titles
Full title
FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_82572909d6d141f9893068bc97990bd4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_82572909d6d141f9893068bc97990bd4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49202-3
