Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its...
Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is elicited cannot be overcome. Here we show that a proteostatic insult, provoked by persistent expr...
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Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude
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TN_cdi_doaj_primary_oai_doaj_org_article_82a452a9f3054c8380db9538d5ae73c9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_82a452a9f3054c8380db9538d5ae73c9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.27518
