Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation...
Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
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Beijing: Higher Education Press
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English
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Beijing: Higher Education Press
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TRPML1 channel is a non-selective group-2 transient receptor potential （TRP） channel with Ca2＋ permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane trafficking, and lysosome biogenesis. Mutations of TRPML1 cause a severe lysosomal storage disorder c...
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Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_82c2ab91eeb144e38ffbcb2e0355ba1d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_82c2ab91eeb144e38ffbcb2e0355ba1d
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ISSN
1674-800X
E-ISSN
1674-8018
DOI
10.1007/s13238-017-0476-5
