Design and Synthesis of Brefeldin A-Isothiocyanate Derivatives with Selectivity and Their Potential...
Design and Synthesis of Brefeldin A-Isothiocyanate Derivatives with Selectivity and Their Potential for Cervical Cancer Therapy
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Author / Creator
Wang, Mingying , Chen, Xiaoyuan , Qu, Ying , Ma, Qingyinglu , Pan, Huaqi , Li, Haonan , Hua, Huiming and Li, Dahong
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Brefeldin A has a wide range of anticancer activity against a variety of tumor cells. Its poor pharmacokinetic properties and significant toxicity seriously hinder its further development. In this manuscript, 25 brefeldin A-isothiocyanate derivatives were designed and synthesized. Most derivatives showed good selectivity between HeLa cells and L-02...
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Full title
Design and Synthesis of Brefeldin A-Isothiocyanate Derivatives with Selectivity and Their Potential for Cervical Cancer Therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_82c990d822f147c5adaa6fb4de74b7f9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_82c990d822f147c5adaa6fb4de74b7f9
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules28114284
