Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drug...
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
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Author / Creator
Park, Tae-Eun , Mustafaoglu, Nur , Herland, Anna , Hasselkus, Ryan , Mannix, Robert , FitzGerald, Edward A. , Prantil-Baun, Rachelle , Watters, Alexander , Henry, Olivier , Benz, Maximilian , Sanchez, Henry , McCrea, Heather J. , Goumnerova, Liliana Christova , Song, Hannah W. , Palecek, Sean P. , Shusta, Eric and Ingber, Donald E.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced pluripotent stem cell-derived human brain microvascular endothelium interfaced with primary human brain...
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Full title
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
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TN_cdi_doaj_primary_oai_doaj_org_article_83253cf0aed94f3c93f14d16e82efff7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_83253cf0aed94f3c93f14d16e82efff7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10588-0
