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Reduced TREM2 activation in microglia of patients with Alzheimer's disease

Reduced TREM2 activation in microglia of patients with Alzheimer's disease

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8348c8f569ac42c08252824badf04b3e

Reduced TREM2 activation in microglia of patients with Alzheimer's disease

About this item

Full title

Reduced TREM2 activation in microglia of patients with Alzheimer's disease

Publisher

England: John Wiley & Sons, Inc

Journal title

FEBS open bio, 2021-11, Vol.11 (11), p.3063-3080

Language

English

Formats

Publication information

Publisher

England: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD). The mechanism through which TREM2 contributes to the disease (TREM2 activation vs inactivation) is largely unknown. Here, we analyzed changes in a gene set downstream of TREM2 to determine whether TREM2 sig...

Alternative Titles

Full title

Reduced TREM2 activation in microglia of patients with Alzheimer's disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8348c8f569ac42c08252824badf04b3e

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8348c8f569ac42c08252824badf04b3e

Other Identifiers

ISSN

2211-5463

E-ISSN

2211-5463

DOI

10.1002/2211-5463.13300

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