A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyper...
A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia
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Cambridge: eLife Sciences Publications Ltd
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English
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Cambridge: eLife Sciences Publications Ltd
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Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation during diabetic hyperglycemia. Experiments in apyrase-treated cells suggest...
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A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia
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TN_cdi_doaj_primary_oai_doaj_org_article_834ddbe5b2af4b2d9cbfe39b3182cbe7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_834ddbe5b2af4b2d9cbfe39b3182cbe7
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.42214
