Probing PAC1 receptor activation across species with an engineered sensor
Probing PAC1 receptor activation across species with an engineered sensor
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1
, a novel genetically encoded sensor based on a class-B1 GPCR (the human PAC1 receptor, hmPAC1R) endowed with high dynamic...
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Full title
Probing PAC1 receptor activation across species with an engineered sensor
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TN_cdi_doaj_primary_oai_doaj_org_article_83a204a88f8b464d90811cb0b5e39796
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_83a204a88f8b464d90811cb0b5e39796
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.96496
