Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
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Author / Creator
DeSisto, John , Lucas, John T. , Xu, Ke , Donson, Andrew , Lin, Tong , Sanford, Bridget , Wu, Gang , Tran, Quynh T. , Hedges, Dale , Hsu, Chih-Yang , Armstrong, Gregory T. , Arnold, Michael , Bhatia, Smita , Flannery, Patrick , Lemma, Rakeb , Hardie, Lakotah , Schüller, Ulrich , Venkataraman, Sujatha , Hoffman, Lindsey M. , Dorris, Kathleen , Mulcahy Levy, Jean M. , Hankinson, Todd C. , Handler, Michael , Liu, Arthur K. , Foreman, Nicholas , Vibhakar, Rajeev , Jones, Kenneth , Allen, Sariah , Zhang, Jinghui , Baker, Suzanne J. , Merchant, Thomas E. , Orr, Brent A. and Green, Adam L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing on 32 RIG tumors and an in vitro drug screen in two RIG cell lines. We report that based on DNA methylation, RIGs cluster primarily with the pediatric receptor tyrosine kina...
Alternative Titles
Full title
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
Authors, Artists and Contributors
Author / Creator
Lucas, John T.
Xu, Ke
Donson, Andrew
Lin, Tong
Sanford, Bridget
Wu, Gang
Tran, Quynh T.
Hedges, Dale
Hsu, Chih-Yang
Armstrong, Gregory T.
Arnold, Michael
Bhatia, Smita
Flannery, Patrick
Lemma, Rakeb
Hardie, Lakotah
Schüller, Ulrich
Venkataraman, Sujatha
Hoffman, Lindsey M.
Dorris, Kathleen
Mulcahy Levy, Jean M.
Hankinson, Todd C.
Handler, Michael
Liu, Arthur K.
Foreman, Nicholas
Vibhakar, Rajeev
Jones, Kenneth
Allen, Sariah
Zhang, Jinghui
Baker, Suzanne J.
Merchant, Thomas E.
Orr, Brent A.
Green, Adam L.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_83b97f7c6e28476688641217970f4a3f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_83b97f7c6e28476688641217970f4a3f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25709-x
