Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obes...
Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glycolysis and protects mice from obesity and fatty liver disease. GPR3 activation induces a rapid increase in glyc...
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Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_83d25661a3af40cb9b261bb33f972632
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_83d25661a3af40cb9b261bb33f972632
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45167-5
