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SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic termin...

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic termin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8405b7ea05e8461086f8fdd56ee7dec8

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

About this item

Full title

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2019-11, Vol.10 (1), p.5448-17, Article 5448

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Amphisomes are organelles of the autophagy pathway that result from the fusion of autophagosomes with late endosomes. While biogenesis of autophagosomes and late endosomes occurs continuously at axon terminals, non-degradative roles of autophagy at boutons are barely described. Here, we show that in neurons BDNF/TrkB traffick in amphisomes that sig...

Alternative Titles

Full title

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8405b7ea05e8461086f8fdd56ee7dec8

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8405b7ea05e8461086f8fdd56ee7dec8

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-13224-z

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