Pyrazinamide triggers degradation of its target aspartate decarboxylase
Pyrazinamide triggers degradation of its target aspartate decarboxylase
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in
Mycobacterium tuberculosis
by binding to aspartate decarboxylase PanD. While most drugs act by in...
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Full title
Pyrazinamide triggers degradation of its target aspartate decarboxylase
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TN_cdi_doaj_primary_oai_doaj_org_article_840f3d486eeb4f43af457982724b4b9d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_840f3d486eeb4f43af457982724b4b9d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15516-1
