Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes b...
Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Production of the anticancer drug Taxol and its precursors in heterologous hosts is more sustainable than extraction from tissues of yew trees or chemical synthesis. Although attempts to engineer the Taxol pathway in microbes have made significant progress, challenges such as functional expression of plant P450 enzymes remain to be addressed. Here,...
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Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana
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TN_cdi_doaj_primary_oai_doaj_org_article_8428c9211e514f2db08b62a0cc8920f5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8428c9211e514f2db08b62a0cc8920f5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12879-y
