An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persis...
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
About this item
Full title
Author / Creator
Lee, Chang-Han , Kang, Tae Hyun , Godon, Ophélie , Watanabe, Makiko , Delidakis, George , Gillis, Caitlin M. , Sterlin, Delphine , Hardy, David , Cogné, Michel , Macdonald, Lynn E. , Murphy, Andrew J. , Tu, Naxin , Lee, Jiwon , McDaniel, Jonathan R. , Makowski, Emily , Tessier, Peter M. , Meyer, Aaron S. , Bruhns, Pierre and Georgiou, George
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life by virtue of more favorable pH-dependent binding to hFcRn are of great therapeutic interest. Here we...
Alternative Titles
Full title
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Authors, Artists and Contributors
Author / Creator
Kang, Tae Hyun
Godon, Ophélie
Watanabe, Makiko
Delidakis, George
Gillis, Caitlin M.
Sterlin, Delphine
Hardy, David
Cogné, Michel
Macdonald, Lynn E.
Murphy, Andrew J.
Tu, Naxin
Lee, Jiwon
McDaniel, Jonathan R.
Makowski, Emily
Tessier, Peter M.
Meyer, Aaron S.
Bruhns, Pierre
Georgiou, George
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_84d23b07351d4847b7e49dca2fbb568c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_84d23b07351d4847b7e49dca2fbb568c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13108-2
