Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
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Author / Creator
El Karoui, Khalil , Viau, Amandine , Dellis, Olivier , Bagattin, Alessia , Nguyen, Clément , Baron, William , Burtin, Martine , Broueilh, Mélanie , Heidet, Laurence , Mollet, Géraldine , Druilhe, Anne , Antignac, Corinne , Knebelmann, Bertrand , Friedlander, Gérard , Bienaimé, Frank , Gallazzini, Morgan and Terzi, Fabiola
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions, which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid (PBA), a chemical chaperone already used in humans, as a novel therapeutic strategy capable to counteract the toxic effect of proteinuria. Mechanistically, we show that al...
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Full title
Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
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TN_cdi_doaj_primary_oai_doaj_org_article_84d6beb4c2bc4aa9bafacf3ebe31468b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_84d6beb4c2bc4aa9bafacf3ebe31468b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10330
