Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcrip...
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
About this item
Full title
Author / Creator
Pastore, Alessandro , Gaiti, Federico , Lu, Sydney X. , Brand, Ryan M. , Kulm, Scott , Chaligne, Ronan , Gu, Hongcang , Huang, Kevin Y. , Stamenova, Elena K. , Béguelin, Wendy , Jiang, Yanwen , Schulman, Rafael C. , Kim, Kyu-Tae , Alonso, Alicia , Allan, John N. , Furman, Richard R. , Gnirke, Andreas , Wu, Catherine J. , Melnick, Ari M. , Meissner, Alexander , Bernstein, Bradley E. , Abdel-Wahab, Omar and Landau, Dan A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively study the epigenetic dimension of cancer evolution, we integrate DNAme analysis with histone modification mapping and single cell analyses of R...
Alternative Titles
Full title
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
Authors, Artists and Contributors
Author / Creator
Gaiti, Federico
Lu, Sydney X.
Brand, Ryan M.
Kulm, Scott
Chaligne, Ronan
Gu, Hongcang
Huang, Kevin Y.
Stamenova, Elena K.
Béguelin, Wendy
Jiang, Yanwen
Schulman, Rafael C.
Kim, Kyu-Tae
Alonso, Alicia
Allan, John N.
Furman, Richard R.
Gnirke, Andreas
Wu, Catherine J.
Melnick, Ari M.
Meissner, Alexander
Bernstein, Bradley E.
Abdel-Wahab, Omar
Landau, Dan A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_84f8fc2c23c040aca441459292bfd167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_84f8fc2c23c040aca441459292bfd167
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09645-5
