A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
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Germany: Beilstein-Institut zur Föerderung der Chemischen Wissenschaften
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English
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Germany: Beilstein-Institut zur Föerderung der Chemischen Wissenschaften
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Oxoisoaporphine alkaloids are conveniently prepared via direct ring metalation of alkoxy-substituted isoquinolines at C-1, followed by reaction with iodine. Subsequent Suzuki cross-coupling of the resulting 1-iodoisoquinolines to methyl 2-(isoquinolin-1-yl)benzoates and intramolecular acylation of the corresponding carboxylic acids with Eaton’s rea...
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Full title
A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
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TN_cdi_doaj_primary_oai_doaj_org_article_84ff6658adc34d119c11aba8f3bf8ca1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_84ff6658adc34d119c11aba8f3bf8ca1
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ISSN
1860-5397,2195-951X
E-ISSN
1860-5397
DOI
10.3762/bjoc.13.156
