High-grade serous ovarian carcinoma organoids as models of chromosomal instability
High-grade serous ovarian carcinoma organoids as models of chromosomal instability
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Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous
TP53
mutation, profound chromosomal instability, and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can be distinguished by specific copy number signatures. To develop clinically relevant models of...
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Full title
High-grade serous ovarian carcinoma organoids as models of chromosomal instability
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TN_cdi_doaj_primary_oai_doaj_org_article_850eb78c25664e2982c8900a7a2a9606
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_850eb78c25664e2982c8900a7a2a9606
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.83867
