A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal gl...
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
About this item
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Author / Creator
Takase, Shohei , Hiroyama, Takashi , Shirai, Fumiyuki , Maemoto, Yuki , Nakata, Akiko , Arata, Mayumi , Matsuoka, Seiji , Sonoda, Takeshi , Niwa, Hideaki , Sato, Shin , Umehara, Takashi , Shirouzu, Mikako , Nishigaya, Yosuke , Sumiya, Tatsunobu , Hashimoto, Noriaki , Namie, Ryosuke , Usui, Masaya , Ohishi, Tomokazu , Ohba, Shun-ichi , Kawada, Manabu , Hayashi, Yoshihiro , Harada, Hironori , Yamaguchi, Tokio , Shinkai, Yoichi , Nakamura, Yukio , Yoshida, Minoru and Ito, Akihiro
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations. Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic modulators, including G9a inhibitors, have been proposed as therapeutic agents. However, the molecular mechanisms whereby these small molecules reactivate γ-globin remain uncle...
Alternative Titles
Full title
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
Authors, Artists and Contributors
Author / Creator
Hiroyama, Takashi
Shirai, Fumiyuki
Maemoto, Yuki
Nakata, Akiko
Arata, Mayumi
Matsuoka, Seiji
Sonoda, Takeshi
Niwa, Hideaki
Sato, Shin
Umehara, Takashi
Shirouzu, Mikako
Nishigaya, Yosuke
Sumiya, Tatsunobu
Hashimoto, Noriaki
Namie, Ryosuke
Usui, Masaya
Ohishi, Tomokazu
Ohba, Shun-ichi
Kawada, Manabu
Hayashi, Yoshihiro
Harada, Hironori
Yamaguchi, Tokio
Shinkai, Yoichi
Nakamura, Yukio
Yoshida, Minoru
Ito, Akihiro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_854cca959e544001b639a7418e25c89f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_854cca959e544001b639a7418e25c89f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35404-0
